miRNAs predict poor outcome in breast cancer patients with luminal A tumors Blood protein EPO involv

The tumor microenvironment, niotillfem including the stromal tissue that surrounds cancer cells, plays a significant role tumor growth and metastasis. Carcinoma Associated Fibroblasts (CAFs) are stromal cells that secrete growth and other factors niotillfem that promote cancer niotillfem progression and metastasis. A study from the University of Colorado by Pinto et al. investigated secreted factors from tumor stromal niotillfem cells from luminal breast cancer using malignant mouse fibroblasts BJ3Z cells. Although luminal breast cancer is less aggressive than other subtypes, one third of these cancers still recur with hormone resistance. This study investigated the role of the stromal fibroblast cells in promoting luminal tumor cells to proliferate and promote angiogenesis.
When co-cultured with MCF-7 cells, luminal breast cancer cells, BJ3Z cells increased proliferation niotillfem of the luminal cells in 2D and 3D cultures. Platelet derived Growth niotillfem Factor niotillfem Ligands (PDGF-A and –B) was found to be produced by BJ3Z cells, but lack the PDGF receptors themselves unlike normal mammary fibroblasts. PDGF induces angiogenesis, and was found to regulate Human Umbilical Cord Vascular Endothelial Cells (HUVEC) in vitro. The growth observed in MCF-7 cells from PDGF-A and –B secreted by the BJ3Z cells could be blocked by a PDGF receptor inhibitor. Importantly, this study makes a case for using therapies that target niotillfem breast cancer niotillfem stromal cells. For luminal cancers, Imatinib, or other anti-PDGF receptor therapies could be used to target cancer-associated fibroblasts. This study was published in BMC Cancer online on October 1, 2014. 
Malignant stroma increases luminal breast cancer cell proliferation and angiogenesis niotillfem through platelet-derived growth factor signaling. Mauricio P Pinto, Wendy W Dye, Britta M Jacobsen and Kathryn B Horwitz. niotillfem BMC Cancer, 2014. doi:10.1186/1471-2407-14-735
Hot on the trail of the hepatitis-liver cancer connection
miRNAs predict poor outcome in breast cancer patients with luminal A tumors Blood protein EPO involved in origin and spread of cancer Short chromosome ends in breast stem cells indicate susceptibility to breast cancer Jefferson niotillfem researchers provide genetic evidence that antioxidants can help treat cancer Differential expression of long non-coding RNA found in breast cancer

Dr. ibiza spotlight Jonathan Braun's research is focused on the molecular basis of disease-related i

Jonathan Braun, M.D., Ph.D. Professor and Chair, Department of Pathology and Laboratory Medicine; Professor, Department of Molecular and Medical Pharmacology; Co-Director, JCCC Tumor Immunology ibiza spotlight Program Area.
Dr. ibiza spotlight Jonathan Braun's research is focused on the molecular basis of disease-related immune processes. Innate and adaptive immune functions play a major role in susceptibility to and outcome of infectious diseases, autoimmunity and cancer.
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Breast cancer is a very heterogeneous disease, with a high degree of diversity between and within tu

Related literature Cited by Google blog search Other articles by authors   on Google Scholar Leccia F Del Vecchio L Mariotti E Di Noto R Morel AP Puisieux A Salvatore F Ansieau S   on PubMed Leccia F Del Vecchio L Mariotti E Di Noto R Morel AP Puisieux A Salvatore F Ansieau echostage S Related articles/pages on Google on Google Scholar on PubMed Tools Download references Download XML Email to a friend Order reprints Post a comment   Download to ... Papers Mendeley Download echostage to ... Papers Mendeley Share this article
Felicia Leccia 1 10 2 3 4 5 6 * , Luigi Del Vecchio 1 7 , Elisabetta Mariotti 1 7 , Rosa Di Noto 1 7 , Anne-Pierre Morel 2 3 4 5 6 , Alain Puisieux echostage 2 3 4 5 6 8 , Francesco Salvatore 1 7 9 * and Stéphane Ansieau 2 3 4 5 6
Molecular Cancer 2014, 13 :213  doi:10.1186/1476-4598-13-213
The electronic version of this article is the complete echostage one and can be found online at: http://www.molecular-cancer.com/content/13/1/213 Received: 23 April 2014 Accepted: echostage 4 September 2014 Published: 12 September 2014
This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( http://creativecommons.org/licenses/by/4.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Tumor-initiating cells (TICs), aka cancer stem cells , are believed to fuel tumors and to sustain therapy resistance and systemic metastasis. Breast cancer is the first human carcinoma in which a subpopulation of cells displaying a specific CD44 + /CD24 -/low /ESA + antigenic phenotype was found to have TIC properties. However, CD44 + /CD24 -/low /ESA + is not a universal marker phenotype of TICs in all breast cancer subtypes. The aim of this study was to identify novel antigens with which to isolate the TIC population of the basal-A/basal-like echostage breast cancer cell lines. Methods
We used polychromatic flow-cytometry to characterize the cell surface of several breast cancer cell lines that may represent different tumor molecular subtypes. We next used fluorescence-activated cell sorting to isolate echostage the cell subpopulations of interest from the cell lines. Finally, we explored the stem-like and tumorigenic properties of the sorted cell subpopulations using complementary in vitro and in vivo approaches: echostage mammosphere formation assays, soft-agar colony assays, and tumorigenic assays in NOD/SCID mice. Results
The CD44 + /CD24 + subpopulation of the BRCA1 -mutated basal-A/basal-like cell line HCC1937 is enriched in several echostage stemness markers, including the ABCG2 transporter (i.e., the CD338 antigen). Consistently, CD338-expressing cells were also enriched in CD24 expression, suggesting that coexpression of these two antigenic markers may segregate echostage TICs in this cell line. In support of ABCG2 expression in TICs, culturing echostage of HCC1937 cells in ultra-low adherent conditions to enrich echostage them in precursor/stem-cells resulted in an increase in CD338-expressing cells. Furthermore, CD338-expressing cells, unlike their CD338-negative counterparts, displayed stemness and transformation potential, as assessed in mammosphere and colony formation assays. Lastly, CD338-expressing cells cultured in ultra-low adherent conditions maintained the expression of CD326/EpCAM and CD49f/α6-integrin, which is a combination of antigens previously assigned to luminal progenitors. Conclusion
Collectively, our data suggest that CD338 expression is specific to the tumor-initiating luminal progenitor subpopulation of BRCA1 -mutated cells and is a novel antigen with which to sort this subpopulation. Keywords: Basal-like breast cancer (BLBC); Tumor-initiating cells (TICs); CD338/ABGG2; Antigenic phenotype Introduction
Breast cancer is a very heterogeneous disease, with a high degree of diversity between and within tumors. echostage The intertumoral heterogeneity is exemplified by the identification of five molecular subtypes, namely HER2+, echostage normal-like, luminal echostage (subtypes A and B), basal A/basal-like and basal B/claudin-low a classification based on gene expression profile analysis [ 1 - 5 ]. This heterogeneity stems from the fact that the tumor phenotype varies based on the cell of origin [ 6 ]. Indeed, basal A/basal-like and basal B/claudin-low breast cancer subtypes were reported to result from the transformation of luminal progenitors and basal/myoepithelial cells, respectively [ 5 , 7 - 10 ]. This hypothesis has recently been challenged by the finding that a combination of several genetic events in luminal-committed echostage cells leads to the development of breast cancers of the claudin-low subtype in murine models echostage [ 11 , 12 ]. These genetic events promote echostage an embryonic transdifferentiation program, namely, the epithelial-mesenchymal transition (EMT), a

Deep rolling the pub vibes here from Revolver

Deep rolling the pub vibes here from Revolver & Leona on the remix flex with a class take on Adeh’s Luminal track. the pub The Sheffield duo are going from strength to strength. Their next release on Back2You is a house track called Start Again out on Inception Voluem2 Follow Revolver & Leona on SoundCloud
Future and past Revolver & Leona feature on BBC Introducing #SundayChill Happy New year Back2You the pub on the remix of Joe Nebula and Rachel Harris track Joy Trimer Extraordinary best of the year on EDM.com DrumNBass.net Thanks and looking the pub forward the pub to 2015 Back2You Radio Show with Joe Nebula and guest Omen Breaks. 97.5 Kemet FM Inception Volume 2 – Our Bass Addiction review Inception Volume 2 out now Inception Volume 2 – BBC Introducing Music for Africa. The Collective Inception Volume 2 Free Download of Joe Nebula & Patricia Edwards track – Matter Not Revolver & Leona on the remix flex of Adeh – Luminal Back2You the pub invited to play at Rizzla’s Birthday Bash #Jungle Pictures from Displace’s 3rd Birthday with Revolver & Leona Win tickets the pub and jam with Revolver & Leona at Displace Sheffiled The past year with Back2You Sept 2013 – Sept 2014 Warp Factor on BBC Introducing Back2You BIG support form Dj Marky, the pub Fabio & Grooverider Past January 2015 December 2014 November 2014 October 2014 September 2014 August 2014 July 2014 June 2014 May 2014 April 2014 March 2014 February 2014 November 2013 October 2013
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Pentaction Medieval was mentioned on Pocket Tactics and Touch Arcade! Check it out: Touch Arcade Poc

?
DOWNLOAD NOW ON IOS: APPSTORE ! ​ Pentaction: Medieval is a turn-based strategy row14 board-game about chance row14 and skill on the battlefield. Take control row14 of your army in combat, annihilate your foe s troops or capture their King to win. Play the enhanced Tactical game style for the ultimate strategic experience or jump straight into the action in quick battle. Challenge your friends in hot seat multiplayer row14 or take on the AI in solo play. Do you have what it takes to lead your Kingdom to victory? Published by the great team at Hunted Cow Studios. Check out their website HERE Follow us on Twitter @HyperLuminalUK and Like us on Facebook - https://www.facebook.com/HyperLuminalGames Features - Solo Play Against Intelligent AI. - Hot Seat Multiplayer Game Mode. - Two Game Styles (Tactical + Quick Battle). - Unique Hand-Painted Medieval Visuals. - No Distracting In-Game Ads.
For more content from Hyper Luminal Games check out our website: www.hyperluminalgames.com 2D Fantasy Forest Tileset Asset(Now on Sale!) - TILESET Abstraction FREE Infinite Runner on mobile - ABSTRACTION ​ row14
Hi Elmar, We certainly are on twitter row14 here is our handle: @HyperLuminalUK https://twitter.com/HyperLuminalUK The estimated release date for now is the 18th December 2014 but this is dependent on Apple of course
Thanks Baran! We are also on Facebook: https://www.facebook.com/HyperLuminalGames I'll add both details to the top page, don't forget to vote in the poll!
Hi Elmar, Sadly the game will not be free, it's price will be set by our publishing partner Hunted Cow Studios we expect to launch at a $1.99 price point. We love seeing reviews of our games and hope that you are as impressed with the final product as we are!
Joined: Apr 6, 2013 Messages: 67
Hyper Luminal Games , Dec 14, 2014
We are expecting to be accepted by Apple any day now! If all is well we will launch on Friday for iPhone, iPad and iTouch with other platforms to follow in the near future. So far it looks like Android is winning!
Pentaction Medieval was mentioned on Pocket Tactics and Touch Arcade! Check it out: Touch Arcade Pocket Tactics
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Virtual infrastructure is used by most of the world

Companies White Papers logan city council Regions Infrastructure Design Power Cooling Green Modular Data Centers Servers DCIM Downtime Networking Sectors Cloud Computing Big Data Bitcoin Executive Government Supercomputing / HPC Managed Hosting Colocation Storage Jobs Industry Perspectives
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Two cloud management players announced new funding rounds this morning. Luminal , a company that assists in building and managing cloud infrastructure, landed a $10 million round led by New Enterprise Associates, and StrataCloud , a startup that helps manage VMware-based data center environments, raised $2 million in seed funding, also announcing appointment of a new CEO.
Luminal is still very much in stealth and is keeping its purpose secretive. It will compete with configuration management tools like Puppet and Chef, but is not limited to configuration management. It will first be available on Amazon Web Services. The company is taking beta customer signups now. Luminal will grow its engineering team with the funding.
This investment, led by NEA, will allow us to grow our team and expand our beta customer base in advance of general availability of our product, said Josh Stella, founder and CEO of Luminal. We re building solutions logan city council from first principles to tackle logan city council hard problems logan city council in computing, and the strong support we ve received from NEA, Core Capital, Maryland Venture Fund and our other investors helps make that possible.
The complexity of cloud deployments is only increasing with adoption, and there is an escalating need for a cheaper, more scalable way to manage it all, said Harry Weller, logan city council general partner at NEA. Luminal is developing a radically new approach to cloud architecture that leverages ephemeral components to allow for a higher degree logan city council of automation, efficiency and security. StrataCloud builds its future around converged infrastructure management
Founded in 2008, StrataCloud tracks and collects data using algorithms to help store it more efficiently. The solution takes a snapshot every 20 seconds to judge efficiency and uses historical data to predict resource needs for applications. It will compete with VMware s vCenter operation management logan city council software itself as well as with another new entrant, Platform9, logan city council a company started by former VMware veterans . StrataCloud will use the money to market its software to enterprises.
The company sees converged infrastructure management as its future. logan city council In its words, enterprises are moving towards a model for IT in which all elements of an organization’s infrastructure, including networking, storage, compute and security, are delivered as a service.
Virtual infrastructure is used by most of the world’s largest companies, and management of these resources logan city council can be complicated and expensive,” Cohen said. “We have the most mature product for VMware and compute on the market and a clear vision for how to help companies as they adopt converged solutions that incorporate all infrastructure components. We are anticipating the infrastructure management requirements for a software-defined data center and will be well-positioned as it evolves.”
Jason Verge is an Editor/Industry Analyst on the Data Center Knowledge team with a strong background in the data center and Web hosting industries. In the past he s covered all things Internet Infrastructure, including cloud (IaaS, PaaS and SaaS), mass market hosting, managed hosting, enterprise IT spending trends and M&A. He writes about a range of topics at DCK, with an emphasis on cloud hosting. logan city council
Embotics' CEO Jay Litkey announced a new round of funding which supports Embotics growth in the private cloud management space. With our software solution, mid- or large-size organizations and mid-tier service providers can deploy private cloud in their data center in an hour," he said. Read More
Investors continue to see opportunity in the growing market for data center infrastructure management (DCIM) software. Today CiRBA said it has raised $15 million in institutional funding, while Vigilent has lined up $6.7 million from Accel Partners and several "super angels." Read More
Rather logan city council than trying to squash all instances of shadow IT that pop up in your organization, put a plan in place to help manage it. » Read More
White Paper Library Get Your White Papers Featured logan city council in the DCK White Paper Library Advances in Power and Environmental Monitoring for Increasing Efficiency in the Data Center This white paper will follow the money and show where the power is being used within your data center facility, along with the effec

Scientists show the impact of approved drugs on human proteins

A new study from Myles Brown lab in Harvard University identified miRNA regulated by estrogen receptor and is predictive of a poor outcome in breast cancer patients with estrogen receptor positive vintage inns luminal A cancer.   Inner lining cells of mammary ducts which are the luminal cells can be the starting point of breast cancers. Among the four subtypes of luminal cancer, luminal A tumor tend to have higher survival rates as well as low recurrence rates. Luminal A tumor also are found to be estrogen receptor-positive (ER+). vintage inns   miRNAs are small, noncoding RNAs that regulate gene expression vintage inns and can be regulated by estrogen receptor (ER) and regulate breast cancer signaling pathways. In this study, expression of miRNAs was compared between the estrogen-dependent human breast cancer cell line MCF7 and MCF7:2A, an estrogen independent cell line. Seventy-eight miRNAs were found to be differentially expressed including three miRNAs, let-7c, miR-99a andmiR-125b, vintage inns that are ER targets, were significantly decreased in MCF7:2A cells. These ER-target miRNAs were found to be higher in luminal A vs. luminal B tumors. Luminal A and B breast cancers are estrogen receptor positive and/or progesterone receptor positive, while the luminal A subtype is HER2- and low Ki67 and the luminal B subtype vintage inns is HER2+ with high Ki67.   Using data from The Cancer Genome Atlas (TCGA), luminal vintage inns A patients with decreased expression of these miRNAs were also found to have a worse overall survival. Also, it was found that miRNA miR-125b vintage inns targets HER2 and let-7c regulates HER2 protein expression. The authors conclude that “let-7c/miR-99a/miR-125b cluster is group of miRNAs that regulate HER2 protein expression and when lost may lead to worse outcome for patients with luminal A tumors.”
Loss estrogen-regulated vintage inns microRNA expression increases HER2 signaling and is prognostic of poor outcome in luminal breast cancer. Shannon T. Bailey, Thomas Westerling, and Myles Brown. Published Online First November 11, 2014; doi: 10.1158/0008-5472.CAN-14-1041
Scientists show the impact of approved drugs on human proteins
Targeting carcinoma associated fibroblasts may benefit luminal breast cancer treatment ERbeta1 expression commonly found in breast cancer and predicts outcome in tamoxifen-treated breast cancer Some deadly breast cancers share genetic vintage inns features vintage inns with ovarian tumors Differential expression of long non-coding RNA found in breast cancer New Clues For Overcoming Tamoxifen-Resistant Breast Cancer vintage inns

Those interested in participating in the Luminal beta can send an email to beta@luminal.com or visit

FREDERICK, MD August 14, 2014 Luminal , a Maryland-based startup developing next-generation solutions for cloud operations and management, announced it has closed a $10M Series B financing round, led by New Enterprise Associates (NEA). Previous investors, including Core Capital Partners and Maryland Venture Fund, also participated in the round. This brings Luminal s total amount of financing to $13.8M. kursaal
This investment led by NEA will allow us to grow our team and expand our beta customer kursaal base in advance of general availability of our product, said Josh Stella, founder and CEO of Luminal. We re building kursaal solutions from first principles to tackle hard problems in computing, and the strong support we ve received from NEA, Core Capital, Maryland Venture Fund, and our other investors helps make that possible.
Luminal has developed a solution to automate the deployment and operations of cloud-based systems to bring a level of control, efficiency and security previously unattainable in cloud computing. The product will initially be available on Amazon Web Services.
“Truly unlocking the cloud opportunity requires a fundamental shift in application deployment,” said Harry Weller, General Partner at NEA. “The complexity of cloud deployments is only increasing with adoption, and there is an escalating need for a cheaper, more scalable way to manage it all. Luminal is developing kursaal a radically new approach to cloud architecture that leverages ephemeral components to allow for a higher degree of automation, efficiency and security.”
“It s gratifying to invest at the ground floor in a team that has been able to remain focused on its vision and make significant technical progress over the last year,” said Pascal Luck and Managing Director at Core Capital Partners. “Over this short period we have seen an increasing market need for Luminal s product and the recent investment will allow the Company to continue to attract world class talent to drive the technical and business functions of the Company.”
Those interested in participating in the Luminal beta can send an email to beta@luminal.com or visit www.luminal.com . Luminal is hiring experts in language design, distributed computing, and cloud infrastructure to expand its global team.
About Luminal Luminal is a venture-backed kursaal software startup developing next-generation solutions for the operations and maintenance of cloud-based systems. Luminal was founded in 2012 and is based in Frederick, MD and Washington, DC. For additional information, visit www.luminal.com .
About NEA New Enterprise Associates, Inc. (NEA) is a leading venture capital firm focused kursaal on helping entrepreneurs build transformational businesses across multiple stages, sectors, and geographies. With approximately $13 billion in committed capital, NEA invests in information technology, kursaal healthcare, and energy technology companies at all stages in a company’s lifecycle, from seed stage through IPO. The firm’s long track record of successful investing includes more than 175 portfolio company IPOs and more than 300 acquisitions. For additional information, visit www.nea.com .
About Core Capital Core Capital is an leading venture capital firm headquartered kursaal in downtown Washington, D.C., that invests in early-stage ventures and emerging kursaal growth companies kursaal developing or incorporating disruptive, core technologies in high-growth technology sectors such as Cyber Security, Cloud, and Data Analytics . Our focus is on teams and companies in the information technology, digital media, and technology-enabled services arenas, led by seasoned entrepreneurs. For additional information, visit www.core-capital.com
About DBED The Maryland Department of Business and Economic kursaal Development stimulates private investment and creates jobs by attracting new businesses, encouraging kursaal the expansion and retention of existing companies, and providing workforce training and financial assistance to Maryland kursaal companies. The Department promotes the State’s many economic advantages and markets local products and services at home and abroad to spur economic development and international investment, trade and tourism. For additional information, visit www.ChooseMaryland.org.

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Luminal , a startup pubs for sale that wants to help you build and manage your cloud applications, now has $10 million in new funding pubs for sale led by New Enterprise Associates , bringing its total venture funding to about $13.8 million.
The Frederick, Md.-based company is cagey about saying pubs for sale too much about what it does it s taking applications for beta users now but, in general, Luminal will compete with tools like Chef, Puppet (see disclosure), Ansible and Salt . It also claims it will do more than configuration management.
Our solution allows you to declare the composition and orchestration of your cloud infrastructure and we deploy it, operate it to allow immutable patterns, and maintain it until you change the declarations. Deployment is a small part of our value to our customers, company founder Andrew Wright said via email.
We plan to grow the engineering team significantly. We re working on several hard problems from immutable infrastructure as a turnkey infrastructure capability, to writing a declarative and functional domain specific language. These are areas that require specialized talent to do well, and having NEA and our other partners behind us allows us to attract more of that talent. pubs for sale
Disclosure : Puppet Labs is backed by True Ventures, a venture capital firm that is an investor in the parent company pubs for sale of this blog, Giga Omni Media. Om Malik, founder of Giga Omni Media, is also a venture partner at True.
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David H. Nguyen 1 , Haoxu Ouyang 1 , Jian-Hua Mao 2 , Lynn Hlatky 3 , and Mary Helen Barcellos-Hoff 1 , * 1 Department of Radiation Oncology, New York University School of Medicine, New York, New York. 2 Life Sciences Division, Lawrence Berkeley National Laboratory, Berkeley, California. 3 Center of Cancer Systems nabilah Biology, GeneSys Research Institute, Tufts University School of Medicine, St. Elizabeth's Medical Center, nabilah Boston, Massachusetts. * Corresponding Author: Mary Helen Barcellos-Hoff, Department of Radiation Oncology, New York University, School of Medicine, 450 29th Street, Room 321, New York, NY 10016. Phone: 212-263-3021; Fax: 212-263-6274; E-mail: mhbarcellos-hoff{at}nyumc.org
Age and physiologic status, such as menopause, are risk factors for breast cancer. Less clear is what factors influence the diversity of breast cancer. In this study, we investigated the effect of host age on the distribution of tumor subtypes in mouse mammary chimera consisting of wild-type hosts and Trp53 nullizygous epithelium, which undergoes a high rate of neoplastic transformation. Wild-type mammary glands cleared of endogenous epithelium at 3 weeks of age were subsequently transplanted during puberty (5 weeks) or at maturation (10 weeks) with syngeneic nabilah Trp53 -null mammary tissue fragments and monitored for one year. Tumors arose sooner from adult hosts (AH) compared with juvenile hosts (JH). However, compared with AH tumors, JH tumors grew several times faster, were more perfused, exhibited a two-fold higher mitotic index, and were more highly positive for insulin-like growth factor receptor phosphorylation. Most tumors in each setting were estrogen receptor (ER)-positive (80% JH vs. 70% AH), but JH tumors were significantly more ER-immunoreactive ( P = 0.0001) than AH tumors. A differential expression signature (JvA) of juvenile versus adult tumors nabilah revealed a luminal transcriptional program. Centroids of the human homologs of JvA genes showed that JH tumors were more like luminal A tumors and AH tumors were more like luminal B tumors. Hierarchical clustering with the JvA human ortholog gene list segregated luminal A and luminal B breast cancers across datasets. These data support the notion that age-associated host physiology greatly influences the intrinsic subtype of breast cancer. Cancer Res; 74(23); 7149 58. 2014 AACR .
Note: Supplementary nabilah data for this article are available at Cancer Research Online (http://cancerres.aacrjournals.org/). Received May 14, 2014. Revision received September 8, 2014. Accepted September 12, 2014. 2014 American Association for Cancer Research.
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Correction: Diffusion-Weighted Imaging in Cancer: Physical Foundations and Applications nabilah of Restriction Spectrum Imaging Trafficking of T Cells into Tumors CCR5 Receptor Antagonists Block Metastasis to Bone of v-Src Oncogene-Transformed Metastatic Prostate Cancer Cell Lines Efficacy of CAR T-cell Therapy in Large Tumors Relies upon Stromal Targeting by IFN{gamma} Metastases in Immune-Mediated Dormancy: A New Opportunity for Targeting Cancer View all Most Read articles Cited
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And clearly what

Luminal raises $10M to push a new way to manage cloud infrastructure | VentureBeat | Deals | by Jordan Novet
Luminal , a stealthy startup that’s developed what its chief executive describes as a new model for deploying and operating cloud infrastructure, announced today a $10 million round of new funding.
Josh Stella, Luminal’s chief executive and founder, says the architecture of the startup’s technology could give companies security, efficiency, reliability, and cost benefits. But he wasn’t ready to describe it in detail, as it’s still in private beta. And he doesn’t think the technology would compete with any one type of product.
Even if that’s true, Luminal’s funding does fall in with a trend of investors backing new tools for managing infrastructure in clouds. Most recently startups like StrataCloud , Platform9, and StackStorm have benefited.
Stella said Luminal’s technology isn’t meant to replace wild for the night existing services, including configuration-management tools like Puppet, Chef, SaltStack, wild for the night and Ansible, or, for that matter, technologies for bolstering security of applications running in clouds.
And clearly what’s available from cloud providers now isn’t good enough. wild for the night Otherwise Netflix and other companies wouldn’t wild for the night be producing tools that help applications keep running automatically even when some underlying infrastructure goes belly-up.
A few small companies are using the initial product in their own cloud environments on Amazon Web Services in private beta. The product will become available in a public beta later this year, said Stella, who was previously a principal solution wild for the night architect at Amazon Web Services. It’s possible some of Luminal’s technology will become available under an open-source license, he said.
Opus Global Appoints Bruce Grant as Senior wild for the night Vice President and Chief Marketing Officer

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Luminal , a Maryland-based service bb kings nyc that helps businesses manage their cloud deployments, today announced that is has secured a $10 million Series B round led by New Enterprise Associates . This brings the company s total funding to $13.8 million. Previous investors include Core Capital Partners and Maryland Venture Fund, who also participated in this round. Luminal s product will first be available on Amazon Web Services. bb kings nyc
The idea behind the product is to give businesses an easier way to automate their cloud deployments by bringing declarative control, operational efficiency, and intrinsic security to cloud computing. That s about as specific as the company s description of itself gets, however. For the time being, the service remains in private bb kings nyc beta.
With the help of this new funding round, Luminal plans to grow its team and expand its current beta customer base ahead of the full launch of its services. We re building solutions from first principles to tackle bb kings nyc hard problems in computing, and the strong support we ve received from NEA, Core Capital, Maryland Venture bb kings nyc Fund, and our other investors helps make that possible, said Josh Stella, founder and CEO of Luminal, in a statement today.
As Stella told me yesterday, he believes that owning and operating cloud infrastructure is challenging on many levels. It s still hard to ensure that your instances are running the latest configurations, for example. Even when you automate builds, use scripts to do deployment, and use CM tools to update your infrastructure, over time there is configuration drift and variable performance based on neighbors and other factors, he said. Also, keeping your network, security and storage configurations correct and known is a big challenge. bb kings nyc
Luminal comes in by automating all of those management aspects by using what Stella calls ephemeral bb kings nyc and immutable infrastructure patterns bb kings nyc which has the effect of eliminating whole categories of challenges and mitigating others.
Founded 2012     Overview A software startup focused on next generation computing architectures. Luminal is currently developing Fugue.io to bring full declarative control, native security and simplified O&M to the cloud. Location Frederick, Maryland Categories Cloud Computing , Infrastructure , Security , Software Founders Matthew Brinkman , Josh Stella , Andrew Wright bb kings nyc , Dominic Zippilli Website http://www.luminal.io Full profile for Luminal
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